اثر وابسته به دوز تجویز تیموکینون بر میزان استرس اکسیداتیو در بافت کلیه موش صحرایی دیابتی

Background and Objective: Due to important role of enhanced oxidative stress in development of renal disorder in diabetes and with regard to antidiabetic and antioxidant effect of thymoquinone, this study was conducted to evaluate the effect of its administration on renal tissue level of some markers of oxidative stress in diabetic rats. Materials and Methods: In this experimental study, Wistar rats were divided into 5 groups, i.e. control, high dose thymoquinone-treated control (20 mg/kg), diabetic, and thymoquinone-treated diabetic groups (10 and 20 mg/kg). After 4 weeks, tissue level of malondialdehyde and nitrite and activity of superoxide dismutase (SOD) in kidney tissue were measured.  Results: Diabetic rats showed a significant increase in tissue level of malondialdehyde (p<0.01) and nitrite (p<0.05) and a significant reduction in SOD activity (p<0.05) and thymoquinone treatment at a high dose significantly reduced only levels of MDA and nitrite (p<0.05) and SOD activity in treated-diabetic groups was non-significantly higher as compared to diabetics.  Conclusion: Chronic treatment with thymoquinone dose-dependently could attenuate some markers of oxidative stress in renal tissue from diabetic rats.